A recent edition of “Chemical Engineering Progress” (a magazine from the American Institute for Chemical Engineers), has an interesting section on “Microbiome Engineering”, as illustrated on the cover. This subject nicely illustrates the diversity of directions that chemical engineers might find in a career path.
A microbiome is essentially a community of various types of microbes that live in an environment. Most of this section discusses the human gut microbiome, those trillions of bacteria that live in our bodies in the digestive tract. Apparently, of all the cells in a human body, about 57% of them are microbial (i.e. bacteria, yeast, etc.), and the rest are human cells.
The microbiome in the gut contains about 3,000 different microbial species. In recent years evidence has been mounting that these microbes play key roles in human nutrition, metabolic diseases (like diabetes), mood disorders, and immune system regulation and disorders. Recent information suggests that people with a poor gut microbiome may be more susceptible to COVID-19 infection and severe complications, for example. There is a lot still to be learned about what constitutes a “good” gut microbiome, and how to manipulate it to improve health.
Of particular interest to chemical engineers is the question of how to manufacture so-called “living biotherapeutic products” (LBPs) that could be implanted or swallowed to modify the gut microbiome and cure diseases. Most pharmaceuticals are either chemicals (single or mixtures) or inactivated (dead) parts of microbes or viruses (as used in vaccines). Producing a living product that can grow and thrive in the gut is a somewhat new challenge, especially if it needs to be a complex mixture of microbes.
Some of these engineering/manufacturing challenges would include issues like:
- How to shield the manufacturing process and product from oxygen, since many of these gut microbes may be negatively affected by exposure to oxygen (so-called obligate anaerobes).
- How to get the multiple species of microbes assembled into the LBP. Grow them all separately then mix? Some may grow better in the presence of other species, due to their complex nutritional requirements and symbiotic effects. Growing mixtures of microbes is much more difficult to control if they grow at different rates.
- How to ensure the final LBP product is consistently the same every time it’s produced. The growth history of microbes can affect their final performance and capabilities, even if they are genetically the same. What we call “process control” in chemical engineering will be crucial to consistency of products.
This area of Living Biotherapeutic Products of quite a new one, although it has certain similarities to existing industrial processes like the production of baker’s yeast or Bifidobacteria for dairy starter cultures. As the medical science evolves and promising new therapeutics are identified, chemical engineers will definitely be involved in translating these developments into manufacturing processes that meet future needs.
I’ve written various posts in past years about rankings and the potential problems with them, especially if secondary school students try to use them for choosing a university or program. Often, the rankings are not based on factors that actually impact an undergraduate student’s experience very much. Use the search tool in my blog to find these old posts if you want more information.
However, it’s still fun to look at rankings once in a while, and the U.S. News ones came out recently. I’ll focus on engineering rankings, which can be found at this link.
Waterloo Engineering comes out at #57 overall globally, tied with Caltech in Pasadena California. For comparison, Toronto Engineering is slightly higher at #54, and UBC slightly lower at #63. Essentially all similar, given the vagaries and uncertainties of ranking processes.
On a department level at Waterloo, Chemical Engineering made #87, while Electrical Engineering was #25, Civil Engineering was #73, and Mechanical Engineering was #49 globally. Other departments don’t necessarily show up in rankings because of the way U.S. News categorizes things. However, Waterloo ranks #82 in the “Nanoscience and Nanotechnology” category, which could include various departments in Engineering and Science.
Many of the top ranked engineering programs globally are in China, ranking above the usual U.S. and U.K. schools that you might think of. I haven’t looked at their ranking criteria, so I don’t know why the rankings come out the way they do. Just an interesting observation, and a comment on how much engineering research and activity has grown in China in recent decades.
The pandemic situation has generated a lot of interest and activity in UV disinfection, which has been keeping me busy. Whether it’s for masks, air, surfaces or whatever, there are lots of things getting posted and promoted for using UV. There seem to be an overwhelming number of devices and designs being suggested or sold online. Unfortunately there are also a lot of misconceptions, errors and possibly fraudulent claims being promoted. I’m not going to try and address each and every device (there are too many!), but I can provide some basic ideas that one should know or ask about when considering UV devices. If the supplier can’t readily provide answers or details, then something is possibly wrong. Here are a few key confusing points:Continue reading
Schools of all sorts are looking for ways to re-open while minimizing coronavirus transmission risks. Harvard University’s School of Public Health recently issued a downloadable document on “Schools for Health”. In it they suggest a number of administrative and engineering approaches for reducing virus transmission in a classroom and school setting. It’s interesting and worth a look.
Since I teach and do research in some aspects of HVAC (Heating Ventilation and Air Conditioning) and indoor air quality, those parts of the report caught my attention. They are suggesting that people consider using portable air cleaners in the classroom, especially in situations where the HVAC is non-existent or poor. They don’t give a lot of numerical detail behind that recommendation, but it’s fairly easy to work it out. So I’ve done some quick calculations to see where air cleaners might be useful from a more quantitative perspective.Continue reading
“Plus ça change, plus c’est la même chose” (the more things change, the more they continue to be the same thing, attributed to Jean-Baptiste Karr).
In our current pandemic situation there has been lots of confusion, uncertainty and general ignorance on the subject of face masks and reduction of disease transmission. In the screen capture I show the introductory paragraphs of an article published over one century ago, just as the so-called “Spanish Flu” H1N1 pandemic was probably starting but not yet recognized.Continue reading
With the pandemic situation and the move to online classes by many universities, there is discussion about whether to defer starting university until 2021. This is a complex and significant decision, and an engineer (or prospective engineer) would typically use some sort of decision-making strategy. I’ve written about one decision approach, the Kepner-Tregoe method, in the past with respect to choosing a university. For the decision to defer starting university, let’s try a cost-benefit analysis method.Continue reading
Here’s a nice summary article about aerosol viral transmission, by a mechanical engineering professor. The physics of aerosols is a foundational concept in air pollution control.
Sometimes I see people getting concerned about future prospects for chemical engineering careers, usually because of some downturn in the oil and gas markets. I guess we should never stop emphasizing that chemical engineering is much more than oil, gas, and petrochemicals! There is also food, pharmaceuticals, alternative energy, environment, safety, consumer products, plastics, minerals, metals, paper & fibers, etc….
Actually, the next 30 years is probably going to be a very exciting and technically challenging time to be a chemical engineer. The world needs people with the innovation skills to handle new materials and energy processes more than ever. Why is that? Here are a few quick thoughts…Continue reading
An interesting story below about an engineer using his observations in water treatment to innovate and improve work-flow for lots of other companies. A chemical engineering education can lead in lots of different directions!
In 2014, freshly graduated UC Berkeley alum Ryan Chan was working as a chemical engineer at a water purification plant, when he realized that the company was constantly facing equipment downtime. The workers used a maintenance program that helped them track all the breakdowns, but there was a big problem with the software they were using that was slowing them down.
“Everything was desktop based, but the maintenance team, the people that were using it, never sat at a desk,” Chan says.
So Chan realized there had to be a smarter, mobile-first solution for all the blue collar workers across facilities. He wound up teaching himself how to code at night and on weekends, and developed the app while he worked as a chemical engineer, and later as an iOS developer.
In 2016, Chan launched UpKeep, an app developed for facility managers and maintenance workers that allows them to flag things that need repairs and run equipment audits across facilities.
Soap and water is a preferred choice for hand hygiene and reducing microbial and viral contamination. However this isn’t always convenient or available when out walking or shopping for necessities, so the next best thing is a hand sanitizer formulation. The nice commercial ones are in short supply, but it is relatively easy to blend your own if you can access the ingredients. Blending chemicals safely is another chemical engineering specialty. Here’s a recipe for small volumes for home use, with some discussion on the physical chemistry basis for the various components.Continue reading