Microbiome Engineering

A recent edition of “Chemical Engineering Progress” (a magazine from the American Institute for Chemical Engineers), has an interesting section on “Microbiome Engineering”, as illustrated on the cover. This subject nicely illustrates the diversity of directions that chemical engineers might find in a career path.

A microbiome is essentially a community of various types of microbes that live in an environment. Most of this section discusses the human gut microbiome, those trillions of bacteria that live in our bodies in the digestive tract. Apparently, of all the cells in a human body, about 57% of them are microbial (i.e. bacteria, yeast, etc.), and the rest are human cells.

The microbiome in the gut contains about 3,000 different microbial species. In recent years evidence has been mounting that these microbes play key roles in human nutrition, metabolic diseases (like diabetes), mood disorders, and immune system regulation and disorders. Recent information suggests that people with a poor gut microbiome may be more susceptible to COVID-19 infection and severe complications, for example. There is a lot still to be learned about what constitutes a “good” gut microbiome, and how to manipulate it to improve health.

Of particular interest to chemical engineers is the question of how to manufacture so-called “living biotherapeutic products” (LBPs) that could be implanted or swallowed to modify the gut microbiome and cure diseases. Most pharmaceuticals are either chemicals (single or mixtures) or inactivated (dead) parts of microbes or viruses (as used in vaccines). Producing a living product that can grow and thrive in the gut is a somewhat new challenge, especially if it needs to be a complex mixture of microbes.

Some of these engineering/manufacturing challenges would include issues like:

  • How to shield the manufacturing process and product from oxygen, since many of these gut microbes may be negatively affected by exposure to oxygen (so-called obligate anaerobes).
  • How to get the multiple species of microbes assembled into the LBP. Grow them all separately then mix? Some may grow better in the presence of other species, due to their complex nutritional requirements and symbiotic effects. Growing mixtures of microbes is much more difficult to control if they grow at different rates.
  • How to ensure the final LBP product is consistently the same every time it’s produced. The growth history of microbes can affect their final performance and capabilities, even if they are genetically the same. What we call “process control” in chemical engineering will be crucial to consistency of products.

This area of Living Biotherapeutic Products of quite a new one, although it has certain similarities to existing industrial processes like the production of baker’s yeast or Bifidobacteria for dairy starter cultures. As the medical science evolves and promising new therapeutics are identified, chemical engineers will definitely be involved in translating these developments into manufacturing processes that meet future needs.

Rankings Again

Engineering 6 Building, Chemical Engineering

I’ve written various posts in past years about rankings and the potential problems with them, especially if secondary school students try to use them for choosing a university or program. Often, the rankings are not based on factors that actually impact an undergraduate student’s experience very much. Use the search tool in my blog to find these old posts if you want more information.

However, it’s still fun to look at rankings once in a while, and the U.S. News ones came out recently. I’ll focus on engineering rankings, which can be found at this link.

Waterloo Engineering comes out at #57 overall globally, tied with Caltech in Pasadena California. For comparison, Toronto Engineering is slightly higher at #54, and UBC slightly lower at #63. Essentially all similar, given the vagaries and uncertainties of ranking processes.

On a department level at Waterloo, Chemical Engineering made #87, while Electrical Engineering was #25, Civil Engineering was #73, and Mechanical Engineering was #49 globally. Other departments don’t necessarily show up in rankings because of the way U.S. News categorizes things. However, Waterloo ranks #82 in the “Nanoscience and Nanotechnology” category, which could include various departments in Engineering and Science.

Many of the top ranked engineering programs globally are in China, ranking above the usual U.S. and U.K. schools that you might think of. I haven’t looked at their ranking criteria, so I don’t know why the rankings come out the way they do. Just an interesting observation, and a comment on how much engineering research and activity has grown in China in recent decades.

The Future of Chemical Engineering

Sometimes I see people getting concerned about future prospects for chemical engineering careers, usually because of some downturn in the oil and gas markets. I guess we should never stop emphasizing that chemical engineering is much more than oil, gas, and petrochemicals! There is also food, pharmaceuticals, alternative energy, environment, safety, consumer products, plastics, minerals, metals, paper & fibers, etc….

Actually, the next 30 years is probably going to be a very exciting and technically challenging time to be a chemical engineer. The world needs people with the innovation skills to handle new materials and energy processes more than ever. Why is that? Here are a few quick thoughts…

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Meet The Chemical Engineer Who Accidentally Turned Into An Entrepreneur And Just Raised $36 Million For His App

An interesting story below about an engineer using his observations in water treatment to innovate and improve work-flow for lots of other companies. A chemical engineering education can lead in lots of different directions!

In 2014, freshly graduated UC Berkeley alum Ryan Chan was working as a chemical engineer at a water purification plant, when he realized that the company was constantly facing equipment downtime. The workers used a maintenance program that helped them track all the breakdowns, but there was a big problem with the software they were using that was slowing them down.

“Everything was desktop based, but the maintenance team, the people that were using it, never sat at a desk,” Chan says. 

So Chan realized there had to be a smarter, mobile-first solution for all the blue collar workers across facilities. He wound up teaching himself how to code at night and on weekends, and developed the app while he worked as a chemical engineer, and later as an iOS developer.

In 2016, Chan launched UpKeep, an app developed for facility managers and maintenance workers that allows them to flag things that need repairs and run equipment audits across facilities.

Source: Meet The Chemical Engineer Who Accidentally Turned Into An Entrepreneur And Just Raised $36 Million For His App

Hand Sanitizer Blending

Photo by Anna Shvets on Pexels.com

Soap and water is a preferred choice for hand hygiene and reducing microbial and viral contamination. However this isn’t always convenient or available when out walking or shopping for necessities, so the next best thing is a hand sanitizer formulation. The nice commercial ones are in short supply, but it is relatively easy to blend your own if you can access the ingredients. Blending chemicals safely is another chemical engineering specialty. Here’s a recipe for small volumes for home use, with some discussion on the physical chemistry basis for the various components.

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Chemical Engineers and Pandemics

Chemical Engineering: the art and science of creating and operating industrial scale systems for transforming raw materials into useful products.

Photo by Gustavo Fring on Pexels.com

When “chemical engineering” is mentioned, many people think of chemical plants, refineries, and such. That’s one part of it, but it also encompasses many other things, including pharmaceuticals and vaccine manufacture. These days, everyone is talking about and hoping for a vaccine for Covid-19. What does this mean for some chemical engineers and what they need to do?

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Three engineering subjects rank in the world’s top 100 | Engineering | University of Waterloo

See the link below for the full story, but nice to see my department (Chemical Engineering) ranked in the top 100 worldwide.  The two others are Electrical Engineering (49th) and Civil Engineering (51 to 100 range).  Mechanical Engineering ranked in the top 150.

Waterloo Engineering notched three top-100 results in the Quacquarelli Symonds (QS) worldwide university subject rankings released today for 2019.

Source: Three engineering subjects rank in the world’s top 100 | Engineering | University of Waterloo

Chemical Engineering Imagery

My department put together a nice short video about Chemical Engineering.  It shows some quick images of areas where chemical engineers work, such as alternative energy, pharmaceuticals, water, food processing, and others.  And there are more images about the laboratory research and teaching going on in our facilities.  Have a look and see what you think.

Cannabis Air Emissions

With recent moves to permit sales of cannabis in Canada and some U.S. states, commercial operations are popping up in various locations.  Whenever new industries emerge, there are often new environmental impacts to consider and air pollution seems to be an increasingly common problem with cannabis too.  Not from smoking, but rather from the greenhouse operations where it is grown under lights in high-density conditions to save space.  It turns out that these intensive grow operations can have vented air emissions that are rather smelly, as this one news item describes.

Like all plants, cannabis emits volatile chemical compounds at various stages in its growth.  Some work has been reported in research literature, identifying over 200 chemicals in the air, although I suspect that paper missed a lot of odorous sulfur compounds that are often associated with “skunky” smells.  A lot of the odor compounds are terpenes or their relatives (e.g. limonene, pinene, linalool), and the paper mentions cymene, benzaldehyde, nonanal, and decanol as key odor chemicals.  None of these compounds are particularly hazardous (at least at the normally low concentrations found around plants).  None of them are specific to cannabis either.  Lots of them are produced by various plants, in varying amounts and combinations.  A lot of plant-based essential oils that you can buy contain similar chemicals.

The environmental issue arises if the odor interferes with the neighbouring property and their ability to use and enjoy their property.  The Ontario government website has some information about odors and property-owner rights .  Under Ontario’s Environmental Protection Act (Section 14) odor-emitting industries can get into legal trouble because they are emitting a “contaminant” that causes an “adverse effect”.

From an engineering point of view, the control of odorous emissions like this is not unlike many other industries with odour concerns, like sewage treatment plants, rendering plants, some food manufacturers, and some chemical manufacturers.  The first step is containment, so that odor emissions are not just leaking out of the buildings from a multitude of locations.  If everything can be efficiently captured in one or two well-controlled ventilation systems, then emissions controls can be applied to those vent streams before they discharge into the environment.

It’s not clear at this point what type of emission controls are best for both efficiency and cost points of view.  Usually there are several possible solutions, so engineers have to figure out which one is the most cost-effective.  Standard approaches to odor control run a range of technologies from wet scrubbing to activated carbon capture, to biofiltration and possibly photochemical oxidation.  High temperature thermal oxidation is another option, but probably overkill and too expensive for this application.  One solution may not fit all commercial operations either.  Each location would need a thorough engineering analysis and assessment for a good recommendation, which is something done by chemical and environmental engineers (and some mechanical engineers too).  Companies that rushed into production without doing these assessments may get stuck with expensive retro-fits once the Ministry of Environment comes knocking.

So, with every new “industry” there are issues that come up that may or may not have been anticipated by the business people.  Those issues will keep regulators and engineering consultants busy for a while.